Application | Comment | Organism |
---|---|---|
analysis | the enzyme serves as model enzyme for design of specific inhibiors for zinc proteases | Bos taurus |
drug development | the enzyme serves as model enzyme for design of specific inhibiors for zinc proteases | Bos taurus |
Crystallization (Comment) | Organism |
---|---|
crystal structure analysis | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-2-benzyl-3-(4-methoxybenzoyl)propanoic acid | a ketoester substrate analogue | Bos taurus | |
additional information | rational design of mechanism-based irreversible enzyme inhibitors, inhibition mechanism, overview | Bos taurus | |
N-(3-chloropropionyl)-L-phenylalanine | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloprotease | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro | catalytic mechanism involving the Zn2+ ion and residue Glu270 with ester or protein substrates, the tetrahydrate transition state is stabilized by Arg127, overview | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
CPA | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Bos taurus |