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Literature summary for 3.4.17.1 extracted from

  • Kim, D.H.
    Chemistry-based design of inhibitors for carboxypeptidase A (2004), Curr. Top. Med. Chem., 4, 1217-1226.
    View publication on PubMed

Application

Application Comment Organism
analysis the enzyme serves as model enzyme for design of specific inhibiors for zinc proteases Bos taurus
drug development the enzyme serves as model enzyme for design of specific inhibiors for zinc proteases Bos taurus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-benzyl-3-(4-methoxybenzoyl)propanoic acid a ketoester substrate analogue Bos taurus
additional information rational design of mechanism-based irreversible enzyme inhibitors, inhibition mechanism, overview Bos taurus
N-(3-chloropropionyl)-L-phenylalanine
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloprotease Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro catalytic mechanism involving the Zn2+ ion and residue Glu270 with ester or protein substrates, the tetrahydrate transition state is stabilized by Arg127, overview Bos taurus

Synonyms

Synonyms Comment Organism
CPA
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Bos taurus