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Literature summary for 3.4.17.1 extracted from

  • Park, J.D.; Kim, D.H.; Kim, S.J.; Woo, J.R.; Ryu, S.E.
    Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases (2002), J. Med. Chem., 45, 5295-5302.
    View publication on PubMed
Search for more literature for 3.4.17.1

Crystallization (Commentary)

Crystallization (Comment) Organism
complex of enzyme with the inhibitor (S)-N-sulfamoylphenylalaninecrystals are grown by the microdialysis method by equilibrating the protein-inhibitor complex in a solution of 1.2 M LiCl and 20 mM Tris-HCl buffer (pH 7.5) against a reservoir containing 0.2 M LiCl and 20 mM Tris-HCl buffer (pH 7.5) Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-benzyl-3-(N-sulfamoyl)aminopropanoic acid
-
 Bos taurus
(R)-N-sulfamoylphenylalanine
-
 Bos taurus
(S)-2-benzyl-3-(N-sulfamoyl)aminopropanoic acid
-
 Bos taurus
(S)-N-(N-benzylsulfamoyl)phenylalanine
-
 Bos taurus
(S)-N-(N-isopropylsulfamoyl)phenylalanine
-
 Bos taurus
(S)-N-(N-methylsulfamoiyl)phenylalanine
-
 Bos taurus
(S)-N-(N-phenylethylsulfamoyl)phenylalanine
-
 Bos taurus
(S)-N-methyl-N-sulfamoylphenylalanine
-
 Bos taurus
(S)-N-sulfamoylphenylalanine benzyl ester pH 7.5 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P00730
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-(trans-p-chlorocinnamoyl)-L-phenyllactic acid + H2O
-
 Bos taurus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00065
-
 (S)-N-sulfamoylphenylalanine benzyl ester pH 7.5 Bos taurus
0.035
-
 (S)-N-(N-benzylsulfamoyl)phenylalanine pH 7.5 Bos taurus
0.18
-
 (S)-N-(N-methylsulfamoiyl)phenylalanine pH 7.5 Bos taurus
0.18
-
 (S)-N-(N-phenylethylsulfamoyl)phenylalanine pH 7.5 Bos taurus
0.47
-
 (R)-N-sulfamoylphenylalanine pH 7.5 Bos taurus
0.61
-
 (S)-N-(N-isopropylsulfamoyl)phenylalanine pH 7.5 Bos taurus
1.4
-
 (R)-2-benzyl-3-(N-sulfamoyl)aminopropanoic acid pH 7.5 Bos taurus
2.9
-
 (S)-2-benzyl-3-(N-sulfamoyl)aminopropanoic acid pH 7.5 Bos taurus
3.5
-
 (S)-N-methyl-N-sulfamoylphenylalanine pH 7.5 Bos taurus