Literature summary for 3.4.17.1 extracted from

Park, J.D.; Lee, K.J.; Kim, D.H.
A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)-N-methylphenylalanine (2001), Bioorg. Med. Chem., 9, 237-243.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-N-(2-chloroethyl)-N-methylphenylalanine	-	Bos taurus
(S)-N-(2-chloroethyl)-N-methylphenylalanine	-	Bos taurus
rac-2-benzyl-5-chloropentanoic acid	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hippuryl-Phe + H2O	-	Bos taurus	hippuric acid + Phe	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00036	-	(R)-N-(2-chloroethyl)-N-methylphenylalanine	pH 7.5	Bos taurus
0.0016	-	rac-2-benzyl-5-chloropentanoic acid	pH 7.5	Bos taurus
0.0025	-	(S)-N-(2-chloroethyl)-N-methylphenylalanine	pH 7.5	Bos taurus

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Release 2023.1 (January 2023)