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Literature summary for 3.4.16.4 extracted from

  • Coyette, J.; Perkins, H.R.; Polacheck, I.; Shockman, G.D; Ghuysen, J.M.
    Membrane-bound DD-carboxypeptidase and LD-transpeptidase of Streptococcus faecalis ATCC 9790 (1974), Eur. J. Biochem., 44, 459-468.
    View publication on PubMed
Search for more literature for 3.4.16.4

Inhibitors

Inhibitors Comment Organism Structure
benzylpenicillin
-
 Enterococcus faecalis
cephalexin
-
 Enterococcus faecalis
FeSO4
-
 Enterococcus faecalis
Penicillin V
-
 Enterococcus faecalis
Zn2+
-
 Enterococcus faecalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.45
-
 Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala-D-Ala
-
 Enterococcus faecalis
3.8
-
 Nalpha,Nepsilon-Diacetyl-L-Lys-D-Ala-D-Ala
-
 Enterococcus faecalis
7.5
-
 acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala-D-Ala
-
 Enterococcus faecalis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Enterococcus faecalis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Enterococcus faecalis
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Enterococcus faecalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala-D-Ala + H2O
-
 Enterococcus faecalis acetyl-L-Ala-D-Glu-L-Lys(Ac)-D-Ala + D-Ala
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + Gly-Gly acceptors in transpeptidase reaction Enterococcus faecalis Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly-Gly + D-Ala
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Enterococcus faecalis Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-Gly + H2O
-
 Enterococcus faecalis Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + Gly
-
 ?
Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala-D-Ala + H2O
-
 Enterococcus faecalis Nalpha-(beta-1,4 acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)L-Lys-D-Ala + D-Ala
-
 ?
Nalpha-(beta-1,4-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)-L-lysyl-D-alanyl-D-alanine + H2O
-
 Enterococcus faecalis Nalpha-(beta-1,4-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nepsilon-(D-isoasparaginyl)-L-lysyl-D-alanine + D-alanine
-
 ?
UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Enterococcus faecalis ?
-
 ?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Enterococcus faecalis UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 sodium cacodylate buffer Enterococcus faecalis
7
-
 sodium barbital buffer Enterococcus faecalis