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Literature summary for 3.4.13.9 extracted from
- Enhanced prolidase activity and decreased collagen content in breast cancer tissue (2006), Int. J. Exp. Pathol., 87, 289-296.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | prolidase activity is dependent on the interaction of collagen with the beta1-integrin receptor subunit | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is a target in breast cancer therapy | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | required for enzyme activation | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | breast cancer tissue shows high enzyme activity, reduced collagen content and decreased expression of beta1-integrins | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-Pro + H2O | - |
Homo sapiens | Gly + Pro | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prolidase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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