Cloned (Comment) | Organism |
---|---|
cloned in Escherichia coli | Danio rerio |
cloned in Escherichia coli | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Danio rerio | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | Q9NQH7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
centrosomal protein 290 kDa/NPHP6 + H2O | ciliary proteome is screened for proteins with a proline in the second position: 3 candidate substrates centrosomal protein 290 kDa/NPHP6 (CEP290/NPHP6), Alstrom syndrome 1 (ALMS1), and leucine rich repeat containing 50 (LRRC50), known to cause cystic renal disease are shown to be cleaved by ecAPP | Escherichia coli | ? | - |
? | |
leucine rich repeat containing 50 + H2O | ciliary proteome is screened for proteins with a proline in the second position: 3 candidate substrates centrosomal protein 290 kDa/NPHP6 (CEP290/NPHP6), Alstrom syndrome 1 (ALMS1), and leucine rich repeat containing 50 (LRRC50), known to cause cystic renal disease are shown to be cleaved by ecAPP | Escherichia coli | ? | - |
? | |
additional information | ciliary proteome is screened for proteins with a proline in the second position: 3 candidate substrates centrosomal protein 290 kDa/NPHP6 (CEP290/NPHP6), Alstrom syndrome 1 (ALMS1), and leucine rich repeat containing 50 (LRRC50), known to cause cystic renal disease are shown to be cleaved by ecAPP | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ecAPP | ortholog of human X-prolyl aminopeptidase 3 (xpnpep3) | Escherichia coli |
X-prolyl aminopeptidase 3 | - |
Danio rerio |
X-prolyl aminopeptidase 3 | - |
Homo sapiens |
XPNPEP3 | - |
Danio rerio |
XPNPEP3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | in 2 families with an nephronophthisis-like phenotype, homozygous frameshift and splice-site mutations, respectively, are detected in the X-prolyl aminopeptidase 3 gene | Homo sapiens |
malfunction | suppression of zebrafish xpnpep3 phenocopied the developmental phenotypes of ciliopathy morphants, and this effect is rescued by human XPNPEP3 that is devoid of a mitochondrial localization signal, suggesting that the protein might also have mitochondrial-independent activity | Danio rerio |