Literature summary for 3.4.11.9 extracted from

Molinaro, G.; Carmona, A.K.; Juliano, M.A.; Juliano, L.; Malitskaya, E.; Yessine, M.A.; Chagnon, M.; Lepage, Y.; Simmons, W.H.; Boileau, G.; Adam, A.
Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates (2005), Biochem. J., 385, 389-397.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	50% inhibition at 0.01 mM	Homo sapiens
apstatin	50% inhibition at 0.0023 mM	Homo sapiens
additional information	not inhibitory: bestatin, phosphoamidon	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.018	-	K(Dnp)PPGFSPK(Abz)NH2	-	Homo sapiens
0.019	-	K(Dnp)PPK(Abz)NH2	-	Homo sapiens
0.02	-	K(Dnp)PPGK(Abz)NH2	-	Homo sapiens
0.056	-	des-Arg9-bradykinin	pH 7.4, 37°C	Homo sapiens
0.075	-	bradykinin	pH 7.4, 37°C	Homo sapiens
0.837	-	L-Arg-L-Pro-L-Pro	pH 7.4, 37°C	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-
soluble	mutant form with translational stop codon at position 658	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	secreted enzyme mutant with translational stop codon at position 658, N-glycosylated	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
bradykinin + H2O	-	Homo sapiens	Arg + des-Arg-bradykinin	-	?
des-Arg9-bradykinin + H2O	-	Homo sapiens	?	-	?
K(Dnp)PPGFSPK(Abz)NH2 + H2O	-	Homo sapiens	?	-	?
K(Dnp)PPGK(Abz)NH2 + H2O	-	Homo sapiens	?	-	?
K(Dnp)PPK(Abz)NH2 + H2O	-	Homo sapiens	?	-	?
L-Arg-L-Pro-L-Pro + H2O	-	Homo sapiens	L-Arg + L-Pro-L-Pro	-	?

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Release 2023.1 (January 2023)