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Literature summary for 3.4.11.3 extracted from

  • Laeremans, H.; Demaegdt, H.; De Backer, J.P.; Le, M.T.; Kersemans, V.; Michotte, Y.; Vauquelin, G.; Vanderheyden, P.M.
    Metal ion modulation of cystinyl aminopeptidase (2005), Biochem. J., 390, 351-357.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.3

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline competition between 1,10-phenanthroline and the substrate only in presence of EDTA. Inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process Cricetulus griseus
2,2'-bipyridine acetic acid-containing chelators potentiate the inhibitory effect of 2,2'-bipyridine. Efficiacy decreases in the order: diethylenetriamine-N,N,N',N'',N''-pentaacetic acid, EDTA, EGTA Cricetulus griseus
diethylenetriamine-N,N,N',N'',N''-pentaacetic acid weak Cricetulus griseus
EDTA weak Cricetulus griseus
EGTA weak Cricetulus griseus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process Cricetulus griseus
Mg2+ inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process Cricetulus griseus
Zn2+ inhibitory effect of EDTA plus 1,10-phenanthroline can be completely reversed by Zn2+. Ca2+ and Mg2+ increase the potency of Zn2+ for this process Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine-p-nitroanilide + H2O
-
 Cricetulus griseus L-leucine + p-nitroaniline
-
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