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Literature summary for 3.4.11.3 extracted from

  • Itoh, C.; Watanabe, M.; Nagamatsu, A.; Soeda, S.; Kawarabayashi, T.; Shimeno, H.
    Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization (1997), Biol. Pharm. Bull., 20, 20-24.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
amastatin CAP II Homo sapiens
EDTA
-
Homo sapiens
L-methionine form I inhibited, form II slightly activated Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0056
-
S-benzyl-L-cysteine-p-nitroanilide CAP-I Homo sapiens
0.038
-
S-benzyl-L-cysteine-p-nitroanilide CAP-II Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ stimulates Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
1 * 56000 + 1 * 40000, SDS-PAGE Homo sapiens
56000
-
1 * 56000 + 1 * 40000, SDS-PAGE Homo sapiens
61000
-
CAP-I, 1 * 61000, SDS-PAGE Homo sapiens
64000
-
CAP-I, gel filtration Homo sapiens
97000
-
CAP-II, gel filtratrion Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
two forms CAP-I and CAP-II
-

Purification (Commentary)

Purification (Comment) Organism
two forms, CAP-I and CAP-II Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information broad specificity Homo sapiens ?
-
?
S-benzyl-L-cysteine-p-nitroanilide + H2O
-
Homo sapiens S-benzyl-L-cysteine + p-nitroaniline
-
?

Subunits

Subunits Comment Organism
dimer 1 * 56000 + 1 * 40000, SDS-PAGE Homo sapiens
monomer CAP-I, 1 * 61000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 8 CAP-II Homo sapiens
7.4 8 CAP-I Homo sapiens