Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide | displays a substantial potential inhibitory effect on APN/CD13 activity more potently than bestatin. In the concentration range of 0.0008-0.5 mM, the mean optical density of APN/CD13 activity is reduced by 30%, 53.1%, 63.1%, 68.5%, and 70.8%, respectively, for a 30 min exposure and 37.2%, 56.7%, 66.5%, 73.8%, and 76.2%, respectively, for a 60 min exposure | Homo sapiens | |
bestatin | i.e. [2S, 3R]-3-amino-2-hydroxy-(4-phenylbutanoyl)-L-leucine | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | APN is a Zn2+-dependent ectopeptidase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ES-2 cell | has high levels of APN/CD13 | Homo sapiens | - |
HRA cell | had low levels of APN/CD13 | Homo sapiens | - |
ovary cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Leu-4-nitroanilide + H2O | - |
Homo sapiens | L-Leu + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
APN | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the rates of inhibition of APN expression by 0.004, 0.02, and 0.1 mM (S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3-phenylpropanamide are 26%, 59.1%, and 87.7%, respectively. Bestatin (0.1 mM) decreases the expression of APN in ES-2 cells by 62.4% | down |