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Literature summary for 3.4.11.2 extracted from

  • Li, S.H.; Li, G.; Huang, H.M.; Xiong, F.; Mai, X.; Kuang, B.H.; Liu, C.M.; Tu, G.G.
    Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors (2009), Pharmazie, 64, 67-70.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)-amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
-
 Homo sapiens
(2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
-
 Homo sapiens
bestatin
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-p-nitroanilide + H2O
-
 Homo sapiens L-Leu + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Homo sapiens
APN
-
 Homo sapiens
CD13
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0085
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens bestatin
0.0399
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
0.0488
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
0.0698
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
0.0964
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
0.107
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
0.1073
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
0.1153
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide
0.1178
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
0.1416
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)amino]-propanamide
0.1678
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
0.169
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
0.1701
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)-amino]-propanamide
0.1905
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
0.2058
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
0.2875
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
0.2966
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
0.3089
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
0.3091
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylacetyl)-amino]-propanamide
0.3178
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-nitrorophenyl)-1,3,4-thiadiazol-2-yl]-2-[(benzoyl)amino]-propanamide
0.3378
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)-amino]-propanamide
0.3732
-
 in phosphate sodium buffer (pH 7.2, 50 mM), at 37°C Homo sapiens (2R)-N-[5-phenyl-1,3,4-thiadiazol-2-yl]-2-[(phenylsulfonyl)amino]-propanamide