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Literature summary for 3.4.11.2 extracted from

  • Shang, L.; Fang, H.; Zhu, H.; Wang, X.; Wang, Q.; Mu, J.; Wang, B.; Kishioka, S.; Xu, W.
    Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors (2009), Bioorg. Med. Chem., 17, 2775-2784.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
 Homo sapiens
glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
 Homo sapiens
L-alanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
 Homo sapiens
L-cysteinyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Homo sapiens
L-cysteinyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
 Homo sapiens
L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Homo sapiens
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
 Homo sapiens
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Homo sapiens
L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-Lcysteinamide hydrochloride
-
 Homo sapiens
L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Homo sapiens
L-methionyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Homo sapiens
L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
 Homo sapiens
L-ornithyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide
-
 Homo sapiens
L-phenylalanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
L-tyrosyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
-
 Homo sapiens
L-valyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Homo sapiens
L-valyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-cysteinamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-phenylalaninamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(3,5-dinitrobenzoyl)-L-phenylalaninamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(3-phenylpropanoyl)-L-phenylalaninamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-chlorobutanoyl)-L-phenylalaninamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-methoxybenzoyl)-L-phenylalaninamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-nitrobenzoyl)-Lphenylalaninamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-cysteinamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-leucinamide hydrochloride
-
 Homo sapiens
N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-phenylalaninamide hydrochloride
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-p-nitroanilide + H2O
-
 Homo sapiens L-Ala + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Homo sapiens
APN
-
 Homo sapiens
CD13
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0031
-
-
 Homo sapiens bestatin
0.0086
-
-
 Homo sapiens L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.0088
-
-
 Homo sapiens L-methionyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.0098
-
-
 Homo sapiens L-phenylalanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.0103
-
-
 Homo sapiens L-cysteinyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.0148
-
-
 Homo sapiens L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.0155
-
-
 Homo sapiens L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide
0.0165
-
-
 Homo sapiens L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.0304
-
-
 Homo sapiens L-methionyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
0.0332
-
-
 Homo sapiens L-ornithyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.045
-
-
 Homo sapiens L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-Lcysteinamide hydrochloride
0.0492
-
-
 Homo sapiens L-cysteinyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.0585
-
-
 Homo sapiens L-valyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.0588
-
-
 Homo sapiens L-valyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.0895
-
-
 Homo sapiens L-lysyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.1421
-
-
 Homo sapiens L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
0.1476
-
-
 Homo sapiens L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
0.1579
-
-
 Homo sapiens L-isoleucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.1736
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-methoxybenzoyl)-L-phenylalaninamide hydrochloride
0.1737
-
-
 Homo sapiens glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-cysteinamide hydrochloride
0.1809
-
-
 Homo sapiens L-leucyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.1969
-
-
 Homo sapiens L-tyrosyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
0.2024
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-cysteinamide hydrochloride
0.2772
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(3,5-dinitrobenzoyl)-L-phenylalaninamide hydrochloride
0.366
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(3-phenylpropanoyl)-L-phenylalaninamide hydrochloride
0.5215
-
-
 Homo sapiens L-alanyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride
0.6928
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-chlorobutanoyl)-L-phenylalaninamide hydrochloride
1.049
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-cysteinamide hydrochloride
1.39
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(4-nitrobenzoyl)-Lphenylalaninamide hydrochloride
1.457
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-leucinamide hydrochloride
1.539
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(6-aminohexanoyl)-L-phenylalaninamide hydrochloride
2.263
-
-
 Homo sapiens N1-[(2R)-2-amino-3-phenylpropyl]-N-(2,4-dichlorobenzoyl)-L-phenylalaninamide hydrochloride
3.244
-
-
 Homo sapiens glycyl-N1-[(2R)-2-amino-3-phenylpropyl]-L-leucinamide hydrochloride