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Literature summary for 3.4.11.2 extracted from

  • Wang, Q.; Chen, M.; Zhu, H.; Zhang, J.; Fang, H.; Wang, B.; Xu, W.
    Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors (2008), Bioorg. Med. Chem., 16, 5473-5481.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
Sus scrofa
AHPA-Val
-
Sus scrofa
amastatin
-
Sus scrofa
bestatin
-
Sus scrofa
curcumin
-
Sus scrofa
lapstatin
-
Sus scrofa
leuhistin
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-2-furoyl-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-2-furoyl-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-N1-hydroxy-L-lysinamide
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-L-lysine
-
Sus scrofa
N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-N1-hydroxy-L-lysinamide
-
Sus scrofa
pasmmaplin A
-
Sus scrofa
phebestin
-
Sus scrofa
probestin
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-p-nitroanilide + H2O
-
Sus scrofa L-Leu + p-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
amino-peptidase N
-
Sus scrofa
APN
-
Sus scrofa
CD13
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0132
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-N1-hydroxy-L-lysinamide
0.0155
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa bestatin
0.0912
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-N1-hydroxy-L-lysinamide
0.0943
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-N1-hydroxy-L-lysinamide
0.0958
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-N1-hydroxy-L-lysinamide
0.097
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-N1-hydroxy-L-lysinamide
0.1079
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-N1-hydroxy-L-lysinamide
0.108
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(3-nitrobenzoyl)-L-lysine
0.1119
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-N1-hydroxy-L-lysinamide
0.1272
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2,4-dichlorobenzoyl)-L-lysine
0.1587
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-2-furoyl-N1-hydroxy-L-lysinamide
0.1591
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-N1-hydroxy-L-lysinamide
0.1668
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyridin-3-ylcarbonyl)-L-lysine
0.188
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-bromobenzoyl)-L-lysine
0.1974
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(pyrazin-2-ylcarbonyl)-L-lysine
0.2022
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(4-nitrobenzoyl)-L-lysine
0.2151
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-L-lysine
0.2916
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-isonicotinoyl-L-lysine
0.5696
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-cinnamoyl-N1-hydroxy-L-lysinamide
1.121
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-2-furoyl-L-lysine
1.247
-
in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N6-[(benzyloxy)carbonyl]-N2-(2-thienylcarbonyl)-L-lysine