Cloned (Comment) | Organism |
---|---|
expression in human embryonic kidney cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E354G | almost complete loss of activity | Homo sapiens |
E354I | almost complete loss of activity | Homo sapiens |
E354Q | almost complete loss of activity | Homo sapiens |
E388G | almost complete loss of activity | Homo sapiens |
E410G | almost complete loss of activity | Homo sapiens |
H387C/H391C | almost complete loss of activity | Homo sapiens |
H387I/H391I | almost complete loss of activity | Homo sapiens |
additional information | expression of wild-type enzyme in human embryonic kidney cells is associated with significant decrease in proliferation, migration and also reduced anchorage-independent growth. Effects are due to downregulated mRNA and protein expression of chemokine receptor CXCR4 and an inhibition of the stromal cell-derived factor (SDF)-1alpha/CXCL12-mediated migration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-4-nitroanilide + H2O | - |
Homo sapiens | L-Ala + 4-nitroaniline | - |
? |