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Literature summary for 3.4.11.2 extracted from

  • Proost, P.; Mortier, A.; Loos, T.; Vandercappellen, J.; Gouwy, M.; Ronsse, I.; Schutyser, E.; Put, W.; Parmentier, M.; Struyf, S.; Van Damme, J.
    Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration (2007), Blood, 110, 37-44.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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 Sus scrofa
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa in combination with CD26/dipeptidyl peptidase IV, aminopeptidase N processes chemokine ligand CXCL11, but not CXCL8, to generate truncated CXCL11 forms. The truncated CXCL11 fails to induce an intracellular calcium increase but is still able to bind and desensitize CXCR3 for intact CXCL11 signaling. Truncated CXCL11 fails to attract lymphocytes, and further processing by aminopeptidase N results in significant reduction of inhibition of HMVEC migration ?
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 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 commercial product
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Sus scrofa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in combination with CD26/dipeptidyl peptidase IV, aminopeptidase N processes chemokine ligand CXCL11, but not CXCL8, to generate truncated CXCL11 forms. The truncated CXCL11 fails to induce an intracellular calcium increase but is still able to bind and desensitize CXCR3 for intact CXCL11 signaling. Truncated CXCL11 fails to attract lymphocytes, and further processing by aminopeptidase N results in significant reduction of inhibition of HMVEC migration Sus scrofa ?
-
 ?