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Literature summary for 3.4.11.2 extracted from

  • Garde, S.V.; Forte, A.J.; Ge, M.; Lepekhin, E.A.; Panchal, C.J.; Rabbani, S.A.; Wu, J.J.
    Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects (2007), Anticancer Drugs, 18, 1189-1200.
    View publication on PubMed

Application

Application Comment Organism
medicine asparagine-glycine-asparagine-targeted liposomal doxorubicin binds specifically to cells expressing the enzyme. Upon binding, the drug is internalized through the endosomal pathway. In mice bearing human prostate cancer xeongrafts, significant growth inhibition of tumors is observed upon treatment with asparagine-glycine-asparagine-targeted liposomal doxorubicin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
fibrosarcoma cell
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Homo sapiens
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HT-1080 cell
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Homo sapiens
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HUVEC cell
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Homo sapiens
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Kaposi's sarcoma cell Kaposi sarkoma-derived endothelial cell Homo sapiens
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