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Literature summary for 3.4.11.2 extracted from

  • Kotlo, K.; Shukla, S.; Tawar, U.; Skidgel, R.A.; Danziger, R.S.
    Aminopeptidase N reduces basolateral Na+ -K+ -ATPase in proximal tubule cells (2007), Am. J. Physiol. Renal Physiol., 293, F1047-F1053.
    View publication on PubMed

Application

Application Comment Organism
medicine treatment of cell with aminopeptidase N siRNA increases total cellular Na+K+-ATPase activity and basolateral Na+K+-ATPase abundance about twofold. Overexpression of the enzyme reduces Na+K+-ATPase activity and basolateral abundance by 50%. The effect is mediated via angiotensin IV and angiotensin IV receptor signaling Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in LLC-PK1 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15144
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