Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.2 extracted from

  • Albrecht, S.; Defoin, A.; Salomon, E.; Tarnus, C.; Wetterholm, A.; Haeggstroem, J.Z.
    Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors (2006), Bioorg. Med. Chem., 14, 7241-7257.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid
-
Sus scrofa
3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic acid
-
Sus scrofa
3-amino-2-tetralone
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one O-benzyloxime
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one O-methyloxime
-
Sus scrofa
3-amino-3,4-dihydro-1H-naphthalen-2-one oxime
-
Sus scrofa
bestatin
-
Sus scrofa
isothiochroman-3-one
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine-p-nitroanilide + H2O
-
Sus scrofa L-Leu + p-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
AP-N
-
Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid
-
Sus scrofa
0.004
-
isothiochroman-3-one
-
Sus scrofa
0.055
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime
-
Sus scrofa
0.08
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime
-
Sus scrofa
0.11
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime
-
Sus scrofa
0.13
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-methyloxime
-
Sus scrofa
0.26
-
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
-
Sus scrofa 3-amino-2-tetralone
0.0035
-
-
Sus scrofa bestatin
0.5
-
-
Sus scrofa 3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic acid
0.79
-
-
Sus scrofa 3-amino-3,4-dihydro-1H-naphthalen-2-one O-benzyloxime
1.8
-
-
Sus scrofa 3-amino-3,4-dihydro-1H-naphthalen-2-one oxime