Literature summary for 3.4.11.2 extracted from

Reinhold, D.; Biton, A.; Goihl, A.; Pieper, S.; Lendeckel, U.; Faust, J.; Neubert, K.; Bank, U.; Taeger, M.; Ansorge, S.; Brocke, S.
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses (2007), Ann. N. Y. Acad. Sci., 1110, 402-409.

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Application

Application	Comment	Organism
medicine	simultaneous application of inhibitors to dipeptidyl peptidase IV and aminopeptidase N leads to a more profound reduction of the clinical severity of the experimental autoimmune encephalomyelitis compared to the use of dipeptidyl peptidase IV or aminopeptidase N inhibitors alone	Mus musculus
medicine	simultaneous application of inhibitors to dipeptidyl peptidase IV and aminopeptidase N significantly suppresses DNA synthesis and markedly increases TGF-beta1 production in mitogen- or anti-CD3-stimulated T cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
actinonin	-	Homo sapiens
actinonin	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	animals with experimental autoimmune encephalomyelitis	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-cell	mitogen- or anti-CD3-stimulated T-cell. Simultaneous application of inhibitors to dipeptidyl peptidase IV and aminopeptidase N significantly suppresses DNA synthesis and markedly increases TGF-beta1 production	Homo sapiens	-

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Release 2023.1 (January 2023)