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Literature summary for 3.4.11.2 extracted from

  • Kunii, R.; Nemoto, E.; Kanaya, S.; Tsubahara, T.; Shimauchi, H.
    Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13 (2005), J. Periodontal Res., 40, 138-146.
    View publication on PubMed
Search for more literature for 3.4.11.2

Activating Compound

Activating Compound Comment Organism Structure
additional information up-regulation of enzyme expression upon stimulation with interleukin-4 and interleukin-13 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 92.5% inhibition at 1 mM Homo sapiens
bestatin 83.7% inhibition at 1 mM Homo sapiens
EDTA 35.5% inhibition at 5 mM Homo sapiens
additional information no inhibition by pepstatin, phosphoramidon, and aprotinin Homo sapiens
PMSF 4.5% inhibition at 1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface ectoenzyme Homo sapiens 9986
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast gingival Homo sapiens
-
gingiva
-
 Homo sapiens
-
leukocyte polymorphonuclear leukocytes, i.e. PMN, from heparinized venous blood Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glu-Ala-Ala-4-methoxynaphthylamide + H2O
-
 Homo sapiens ?
-
 ?
L-Leu-4-nitroanilide + H2O
-
 Homo sapiens L-Leu + 4-nitroaniline
-
 ?
additional information the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Homo sapiens
CD13
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7.6 assay at, dependent on substrate used Homo sapiens