Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homotypic aggregation, overview, CD13-mediated homotypic aggregation is inhibited by several MAP kinase inhibitors, e.g. herbimycin, phosphatidylinositol-3-kinase inhibitor LY294002, MEK1 inhibitor PD98059, p38 inhibitor SB203580, genistein, and, to a lesser extent, Ro-31-8220 and bisindolylmaleimide I, which are inhibitors of protein kinase C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in signal transduction and monocytic cell adhesion mediating the binding to IgG-receptor FcgammaRs, the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homoypic aggregation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
monocyte | of peripheral blood | Homo sapiens | - |
U-937 cell | promonocytic cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-4-nitroanilide + H2O | - |
Homo sapiens | L-Ala + 4-nitroaniline | - |
? | |
additional information | the enzyme is involved in signal transduction and monocytic cell adhesion mediating the binding to IgG-receptor FcgammaRs, the enzyme expression is down-regulated during homotypic aggregation, while the enzyme induced the homoypic aggregation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |