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Literature summary for 3.4.11.2 extracted from

  • Cowburn, A.S.; Sobolewski, A.; Reed, B.J.; Deighton, J.; Murray, J.; Cadwallader, K.A.; Bradley, J.R.; Chilvers, E.R.
    Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils (2006), J. Biol. Chem., 281, 12458-12467.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
actinonin IC50 is 0.0031 mM Homo sapiens
bestatin IC50 is 0.01 mM Homo sapiens
additional information inhibition by a CD13 blocking antibody, no inhibition by pepstatin, leupeptin, or aprotinin alone or in combination Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme negatively regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils via inhibition of TNF receptor I shedding, mechanism, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
Homo sapiens L-Ala + 4-nitroaniline
-
?
additional information the enzyme negatively regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils via inhibition of TNF receptor I shedding, mechanism, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Homo sapiens
APN
-
Homo sapiens
CD13
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0031
-
IC50 is 0.0031 mM Homo sapiens actinonin
0.01
-
IC50 is 0.01 mM Homo sapiens bestatin