Cloned (Comment) | Organism |
---|---|
expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinonin | IC50 is 0.0031 mM | Homo sapiens | |
bestatin | IC50 is 0.01 mM | Homo sapiens | |
additional information | inhibition by a CD13 blocking antibody, no inhibition by pepstatin, leupeptin, or aprotinin alone or in combination | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme negatively regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils via inhibition of TNF receptor I shedding, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-4-nitroanilide + H2O | - |
Homo sapiens | L-Ala + 4-nitroaniline | - |
? | |
additional information | the enzyme negatively regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils via inhibition of TNF receptor I shedding, mechanism, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
APN | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0031 | - |
IC50 is 0.0031 mM | Homo sapiens | actinonin | |
0.01 | - |
IC50 is 0.01 mM | Homo sapiens | bestatin |