Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, quantitativ expression analysis in monocytes and macrophages of percardial fluid | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | intergral | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-metallopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme plays a role in the modulation of kinins, neuropeptides, and chemotactic mediators as well as in adhesion and cell-cell interactions, it participates in antigen processing and presentation, trimming of peptides protrusing out of MHC class II molecules, and acts in inflammatory processes, interleukin-10 and TGF-beta are involved in enzyme upregulation in monocytes and U-937 cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | of peripheral blood, spleen and tonsils | Homo sapiens | - |
macrophage | high enzyme expression, of percardial fluid | Homo sapiens | - |
monocyte | of percardial fluid | Homo sapiens | - |
additional information | quantitative expression analysis | Homo sapiens | - |
U-937 cell | promonocytic cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-4-nitroanilide + H2O | - |
Homo sapiens | L-Ala + 4-nitroaniline | - |
? | |
additional information | the enzyme plays a role in the modulation of kinins, neuropeptides, and chemotactic mediators as well as in adhesion and cell-cell interactions, it participates in antigen processing and presentation, trimming of peptides protrusing out of MHC class II molecules, and acts in inflammatory processes, interleukin-10 and TGF-beta are involved in enzyme upregulation in monocytes and U-937 cells, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
APN | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |