Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl cyclohexan bestatin | i.e. BE15, strong inhibition | Homo sapiens | |
bestatin | - |
Homo sapiens | |
methyl bestatin | - |
Homo sapiens | |
additional information | inhibitory potency of bestatin and derivatives on enzyme activity, umbilical vein endothelial cell vessel formation, and cell invasion and migration, overview | Homo sapiens | |
tert-butyl bestatin | i.e. BE17, the BE15 derivative has a dual inhibitory effect on invasion and motility on tumor and endothelial cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | - |
Homo sapiens | - |
human umbilical vein endothelial cell | i.e. HUVEC | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Ala + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
APN | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
in vivo assay at | Homo sapiens |