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Literature summary for 3.4.11.2 extracted from

  • Thielitz, A.; Bukowska, A.; Wolke, C.; Vetter, R.; Lendeckel, U.; Wrenger, S.; Hashimoto, Y.; Ansorge, S.; Gollnick, H.; Reinhold, D.
    Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation (2004), Biochem. Biophys. Res. Commun., 321, 795-801.
    View publication on PubMed
Search for more literature for 3.4.11.2

Application

Application Comment Organism
drug development the membrane alanyl aminopeptidase is a target to modulate keratinocyte growth and differentiation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
 Homo sapiens
anti-CD13 antibody WM15
-
 Homo sapiens
bestatin
-
 Homo sapiens
PAQ-22
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface ectopeptidase Homo sapiens 9986
-
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the membrane enzyme is involved in keratinocyte growth and differentiation, inhibition of the enzyme contributes to inhibition of DNA synthesis in proliferating cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell keratinocyte cell line, high activity Homo sapiens
-
keratinocyte primary split-skin keratinocytes, high activity Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
 Homo sapiens L-Ala + 4-nitroaniline
-
 ?
additional information the membrane enzyme is involved in keratinocyte growth and differentiation, inhibition of the enzyme contributes to inhibition of DNA synthesis in proliferating cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alanyl aminopeptidase
-
 Homo sapiens
APN
-
 Homo sapiens
CD13
-
 Homo sapiens
mAAP
-
 Homo sapiens