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Literature summary for 3.4.11.2 extracted from
- Purification and characterization of aminopeptidase N from human plasma (1984), Enzyme, 32, 65-75.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antipain | 47% inhibition at 0.1 mM | Homo sapiens |  |
| chymostatin | 72% inhibition at 0.1 mM | Homo sapiens | |
| leupeptin | 24% inhibition at 0.1 mM | Homo sapiens | |
| methionine | 79% inhibition at 5 mM | Homo sapiens | |
| phenylalanine | 79% inhibition at 5 mM | Homo sapiens | |
| tryptophan | 63% inhibition at 5 mM | Homo sapiens | |
| tyrosine | 59% inhibition at 2.25 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.087 | - |
Ala-2-naphthylamide | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | increase of activity | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 132000 | - |
2 * 132000 | Homo sapiens |
| 210800 | - |
equilibrium centrifugation | Homo sapiens |
| 240000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aminoacyl peptide | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | glycoprotein, 11.6% carbohydrate | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-2-naphthylamide + H2O | - |
Homo sapiens | Ala + 2-naphthylamine | - |
? | |
| aminoacyl peptide | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 132000 | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
stable for at least 30 min | Homo sapiens |
| 65 | - |
completely inactivated after 30 min | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 303 | - |
Ala-2-naphthylamide | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.5 | - |
Homo sapiens |
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