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Literature summary for 3.4.11.2 extracted from
- Intestinal surface amino-oligopeptidases. I. Isolation of two weight isomers and their subunits from rat brush border (1977), J. Biol. Chem., 252, 4922-4928.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | slight inhibition | Rattus norvegicus |  |
| EDTA | - |
Rattus norvegicus | |
| Mg2+ | slight inhibition | Rattus norvegicus | |
| Mn2+ | slight inhibition | Rattus norvegicus | |
| Zn2+ | slight inhibition | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | brush border membrane | Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 71000 | - |
alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE | Rattus norvegicus |
| 91000 | - |
alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE | Rattus norvegicus |
| 91000 | - |
2 * 91000, enzyme II | Rattus norvegicus |
| 180000 | - |
enzyme II, PAGE | Rattus norvegicus |
| 320000 | - |
enzyme I, PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aminoacyl peptide | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | - |
Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aminoacyl peptide | - |
Rattus norvegicus | ? | - |
? | |
| Leu-2-naphthylamide + H2O | - |
Rattus norvegicus | Leu + 2-naphthylamine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 91000, enzyme II | Rattus norvegicus |
| tetramer | alpha,beta, 2 * 91000 + 2 * 71000, enzyme I, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | 90% of maximal activity at pH 7.0 and pH 8.0 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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