Cloned (Comment) | Organism |
---|---|
expressed with a baculovirus expression system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester | PPI-2458, potent inhibitor | Callithrix jacchus | |
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester | PPI-2458, potent inhibitor | Homo sapiens | |
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester | PPI-2458, potent inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Callithrix jacchus | - |
marmoset | - |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
blood | - |
Callithrix jacchus | - |
germinal center | - |
Homo sapiens | - |
additional information | MetAP-2 is not detected in spleen | Mus musculus | - |
spleen | - |
Homo sapiens | - |
spleen | - |
Callithrix jacchus | - |
tonsil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O | - |
Mus musculus | L-Met + Gly-L-Trp-L-Met-L-Asp | - |
? | |
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O | - |
Homo sapiens | L-Met + Gly-L-Trp-L-Met-L-Asp | - |
? | |
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O | - |
Callithrix jacchus | L-Met + Gly-L-Trp-L-Met-L-Asp | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP-2 | - |
Mus musculus |
MetAP-2 | - |
Homo sapiens |
MetAP-2 | - |
Callithrix jacchus |
methionine aminopeptidase-2 | - |
Mus musculus |
methionine aminopeptidase-2 | - |
Homo sapiens |
methionine aminopeptidase-2 | - |
Callithrix jacchus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000245 | - |
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester | recombinant MetAP-2, in 50 mM Hepes, 100 mM MnCl2, 100 mM NaCl, 0.005% (w/v) bovine serum albumin, 0.006% (w/v) 3-[(3-cholamidopropyl)dimethylammonio]propanesulphonic acid, at pH 7.5 | Homo sapiens |