Literature summary for 3.4.11.18 extracted from

Addlagatta, A.; Matthews, B.W.
Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human type 1 methionine aminopeptidase (2006), Protein Sci., 15, 1842-1848.

Search for more literature for 3.4.11.18

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
MetAP1 in complex with ovalicin, hanging drop vapour diffusion method, with 4%-6% PEG 10000 or 12%-16% PEG monomethyl ether 2000, in 100 mM HEPES at pH 5.4-6.2	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
fumagillin	higher affinity to MetAP2 than to MetAP1; lower affinity to MetAP1 than to MetAP2	Homo sapiens
ovalicin	higher affinity to MetAP2 than to MetAP1; lower affinity to MetAP1 than to MetAP2	Homo sapiens
TNP-470	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50579	MetAP2	-
Homo sapiens	P53582	MetAP1	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
MetAP1	isozyme	Homo sapiens
MetAP2	isozyme	Homo sapiens
type 1 methionine aminopeptidase	-	Homo sapiens
type 2 methionine aminopeptidase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)