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Literature summary for 3.4.11.18 extracted from

  • Hu, X.; Addlagatta, A.; Lu, J.; Matthews, B.W.; Liu, J.O.
    Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression (2006), Proc. Natl. Acad. Sci. USA, 103, 18148-18153.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(2,2-dimethylpropanoyl)amino]pyridine-2-carboxamide
-
 Homo sapiens
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(3-phenylpropanoyl)amino]pyridine-2-carboxamide
-
 Homo sapiens
N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[[(1E)-2-methylpropylidene]amino]pyridine-2-carboxamide
-
 Homo sapiens
tert-butyl [2-(4,5-dihydro-1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P53582
-
-

Synonyms

Synonyms Comment Organism
MetAP1
-
 Homo sapiens
type 1 methionine aminopeptidase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 MetAP1 Homo sapiens tert-butyl [2-(4,5-dihydro-1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
0.0029
-
 MetAP1 Homo sapiens N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(2,2-dimethylpropanoyl)amino]pyridine-2-carboxamide
0.0035
-
 MetAP1 Homo sapiens N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[(3-phenylpropanoyl)amino]pyridine-2-carboxamide
0.0064
-
 MetAP1 Homo sapiens N-(4,5-dihydro-1,3-thiazol-2-yl)-3-[[(1E)-2-methylpropylidene]amino]pyridine-2-carboxamide