Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylmorpholin-4-yl)ethanone | - |
Plasmodium falciparum | |
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylphenyl)ethanone | - |
Plasmodium falciparum | |
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-fluoro-2-sulfanylphenyl)ethanone | - |
Plasmodium falciparum | |
1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-methoxy-2-sulfanylphenyl)ethanone | - |
Plasmodium falciparum | |
1-[2-pyridin-2-yl-6-(trifluoromethyl)-3,4-dihydropyrimidin-4-yl]propane-2-thiol | - |
Plasmodium falciparum | |
2-pyridin-2-yl-4-(trifluoromethyl)-6-[2-(trifluoromethyl)benzyl]-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
4-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine | - |
Plasmodium falciparum | |
4-(5-methoxy-2-phenyl-3,4-dihydropyrimidin-4-yl)morpholine | - |
Plasmodium falciparum | |
4-(5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine | - |
Plasmodium falciparum | |
5-chloro-4,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-chloro-4-methyl-6-(4-methylbenzyl)-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-chloro-6-(2-ethylphenyl)-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine | highly selective inhibitor | Plasmodium falciparum | |
5-methoxy-2-phenyl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-ol | - |
Plasmodium falciparum | |
5-methoxy-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-methoxy-6,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-methoxy-6-methyl-2-phenyl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-methoxy-6-methyl-6-phenyl-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
5-methoxy-6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-(2-chlorobenzyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-(benzylsulfanyl)-5-chloro-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-(phenylsulfanyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-benzyl-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-benzyl-5-chloro-4-methyl-2-pyridin-3-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-[(2,4-dichlorophenyl)sulfanyl]-5-methoxy-2-pyridin-2-yl-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | - |
Plasmodium falciparum | |
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-2-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine | - |
Plasmodium falciparum | |
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-3-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine | - |
Plasmodium falciparum | |
N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-4-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine | - |
Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3273 | - |
Met-peptide | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
strains 3D7 and Dd2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | - |
Plasmodium falciparum | Met + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP1b | - |
Plasmodium falciparum |
methionine aminopeptidase 1b | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.232 | - |
Met-peptide | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000112 | - |
- |
Plasmodium falciparum | 5-chloro-6-(2-ethylphenyl)-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.000152 | - |
- |
Plasmodium falciparum | 4-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine | |
0.000158 | - |
- |
Plasmodium falciparum | 5-chloro-4-methyl-6-(4-methylbenzyl)-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.000199 | - |
- |
Plasmodium falciparum | N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-2-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine | |
0.000521 | - |
- |
Plasmodium falciparum | 5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine | |
0.000843 | - |
- |
Plasmodium falciparum | 5-chloro-4,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.000938 | - |
- |
Plasmodium falciparum | 6-(benzylsulfanyl)-5-chloro-4-methyl-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.00102 | - |
- |
Plasmodium falciparum | 1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-methoxy-2-sulfanylphenyl)ethanone | |
0.00104 | - |
- |
Plasmodium falciparum | 6-[(2,4-dichlorophenyl)sulfanyl]-5-methoxy-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.00106 | - |
- |
Plasmodium falciparum | 6-(2-chlorobenzyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | |
0.00106 | - |
- |
Plasmodium falciparum | 6-benzyl-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | |
0.00107 | - |
- |
Plasmodium falciparum | 2-pyridin-2-yl-4-(trifluoromethyl)-6-[2-(trifluoromethyl)benzyl]-1,6-dihydropyrimidine | |
0.00111 | - |
- |
Plasmodium falciparum | 6-(phenylsulfanyl)-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | |
0.00113 | - |
- |
Plasmodium falciparum | 5-methoxy-6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.00118 | - |
- |
Plasmodium falciparum | 1-[2-pyridin-2-yl-6-(trifluoromethyl)-3,4-dihydropyrimidin-4-yl]propane-2-thiol | |
0.00123 | - |
- |
Plasmodium falciparum | 6-[(4-methoxyphenyl)sulfanyl]-2-pyridin-2-yl-4-(trifluoromethyl)-1,6-dihydropyrimidine | |
0.00124 | - |
- |
Plasmodium falciparum | 1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(4-fluoro-2-sulfanylphenyl)ethanone | |
0.00154 | - |
- |
Plasmodium falciparum | 1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylphenyl)ethanone | |
0.0017 | - |
- |
Plasmodium falciparum | 5-methoxy-6,6-dimethyl-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.00217 | - |
- |
Plasmodium falciparum | 5-methoxy-6-methyl-6-phenyl-2-pyridin-2-yl-1,6-dihydropyrimidine | |
0.00312 | - |
- |
Plasmodium falciparum | 1-(5-chloro-6-methyl-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)-2-(2-sulfanylmorpholin-4-yl)ethanone | |
0.00513 | - |
- |
Plasmodium falciparum | 4-(5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-yl)morpholine | |
0.00791 | - |
- |
Plasmodium falciparum | 5-methoxy-2-pyridin-2-yl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | 4-(5-methoxy-2-phenyl-3,4-dihydropyrimidin-4-yl)morpholine | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | 5-methoxy-2-phenyl-6-pyrrolidin-1-yl-1,6-dihydropyrimidine | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | 5-methoxy-2-pyridin-2-yl-3,4-dihydropyrimidin-4-ol | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | 5-methoxy-6-methyl-2-phenyl-1,6-dihydropyrimidine | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | 6-benzyl-5-chloro-4-methyl-2-pyridin-3-yl-1,6-dihydropyrimidine | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-3-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine | |
0.1 | - |
IC50 above 0.1 mM | Plasmodium falciparum | N-(2-aminoethyl)-N'-[5-chloro-6-methyl-2-pyridin-4-yl-4-[5-(trifluoromethyl)pyridin-2-yl]-3,4-dihydropyrimidin-4-yl]ethane-1,2-diamine |