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Literature summary for 3.4.11.18 extracted from

  • Lu, J.; Chong, C.R.; Hu, X.; Liu, J.O.
    Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo (2006), J. Med. Chem., 49, 5645-5648.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3E)-3-(furan-2-ylmethylidene)-5-(hydroxymethyl)-1-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-one no activity at 0.1 mM Homo sapiens
1-methoxy-5-(methoxymethyl)-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-one no activity at 0.1 mM Homo sapiens
2-(5-methoxy-6-[2-methyl-3-((3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hex-1-yl)methyl)-1H-isoindole-1,3(2H)-dione no activity at 0.1 mM Homo sapiens
5-(hydroxymethyl)-1-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-ol no activity at 0.1 mM Homo sapiens
5-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hexane-1-carbaldehyde
-
Homo sapiens
6-(1,5-dimethylhex-4-en-1-yl)-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
-
Homo sapiens
6-[(1E)-1,5-dimethylhexa-1,4-dien-1-yl]-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
-
Homo sapiens
ethyl (6E)-8-[(2R,3R)-3-[(1S,5S)-5-(hydroxymethyl)-1-methoxy-2-oxobicyclo[3.1.0]hex-6-yl]-3-methyloxiran-2-yl]oct-6-enoate no activity at 0.1 mM Homo sapiens
fumagalone
-
Homo sapiens
fumagillin
-
Homo sapiens
fumarranol selective inhibitor Homo sapiens
TNP-470
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Met-peptide + H2O Homo sapiens
-
Met + peptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50579
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Met-peptide + H2O
-
Homo sapiens Met + peptide
-
?

Synonyms

Synonyms Comment Organism
MetAP2
-
Homo sapiens
type 2 methionine aminopeptidase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
-
Homo sapiens TNP-470
0.00323
-
-
Homo sapiens fumarranol
0.008
-
-
Homo sapiens fumagalone
0.0132
-
-
Homo sapiens 5-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hexane-1-carbaldehyde
0.0338
-
-
Homo sapiens 6-[(1E)-1,5-dimethylhexa-1,4-dien-1-yl]-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one
0.0575
-
-
Homo sapiens 6-(1,5-dimethylhex-4-en-1-yl)-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one