Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(2,3-dichlorophenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,3-dimethoxyphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2,3-dimethylphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2,4-dichlorophenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2,5-dichlorophenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2-ethoxyphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2-methoxyphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2-methoxyphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(2-methylphenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2-methylphenyl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | - |
Escherichia coli | |
Fe2+ | - |
Escherichia coli | |
Mn2+ | - |
Escherichia coli | |
Ni2+ | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | Escherichia coli | - |
Met + peptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | - |
Escherichia coli | Met + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP1 | - |
Escherichia coli |
methionine aminopeptidase | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,5-dichlorophenyl)furan-2-carboxylic acid | |
0.00032 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid | |
0.00042 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid | |
0.00044 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,4-dichlorophenyl)furan-2-carboxylic acid | |
0.00048 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)furan-2-carboxylic acid | |
0.00053 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)furan-2-carboxylic acid | |
0.00055 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)furan-2-carboxylic acid | |
0.00067 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid | |
0.00089 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid | |
0.0009 | 4 | Mn(II)-form of the enzyme | Escherichia coli | 5-(2,3-dichlorophenyl)furan-2-carboxylic acid | |
0.00118 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid | |
0.00151 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2-methylphenyl)thiophene-2-carboxylic acid | |
0.00275 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid | |
0.00338 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid | |
0.004 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid | |
0.0046 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.00499 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)thiophene-2-carboxylic acid | |
0.00508 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid | |
0.0077 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.00889 | - |
Mn(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.0095 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid | |
0.0097 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.0099 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.0264 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)furan-2-carboxylic acid | |
0.0273 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)thiophene-2-carboxylic acid | |
0.0286 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid | |
0.03 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,3-dichlorophenyl)furan-2-carboxylic acid | |
0.0357 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid | |
0.0359 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid | |
0.0373 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,4-dichlorophenyl)furan-2-carboxylic acid | |
0.0381 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,5-dichlorophenyl)furan-2-carboxylic acid | |
0.0419 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)furan-2-carboxylic acid | |
0.0457 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)thiophene-2-carboxylic acid | |
0.0477 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,5-dichlorophenyl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,3-dichlorophenyl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,4-dichlorophenyl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2-methylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2-methylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,5-dichlorophenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,3-dichlorophenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,4-dichlorophenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2-methylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.05 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid | |
0.132 | - |
Co(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)furan-2-carboxylic acid | |
0.2 | - |
Fe(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)furan-2-carboxylic acid | |
0.2 | - |
Ni(II)-form of the enzyme | Escherichia coli | 5-(2-methoxyphenyl)furan-2-carboxylic acid |