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Literature summary for 3.4.11.18 extracted from

  • Vedantham, P.; Guerra, J.M.; Schoenen, F.; Huang, M.; Gor, P.J.; Georg, G.I.; Wang, J.L.; Neuenswander, B.; Lushington, G.H.; Mitscher, L.A.; Ye, Q.Z.; Hanson, P.R.
    Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors (2008), J. Comb. Chem., 10, 185-194.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-(2,3-dichlorophenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,3-dimethoxyphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2,3-dimethylphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2,4-dichlorophenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2,5-dichlorophenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2-ethoxyphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2-methoxyphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2-methoxyphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(2-methylphenyl)furan-2-carboxylic acid
-
Escherichia coli
5-(2-methylphenyl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
Escherichia coli
Fe2+
-
Escherichia coli
Mn2+
-
Escherichia coli
Ni2+
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Met-peptide + H2O Escherichia coli
-
Met + peptide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Met-peptide + H2O
-
Escherichia coli Met + peptide
-
?

Synonyms

Synonyms Comment Organism
MetAP1
-
Escherichia coli
methionine aminopeptidase
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00025
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
0.00032
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
0.00042
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
0.00044
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,4-dichlorophenyl)furan-2-carboxylic acid
0.00048
-
Mn(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)furan-2-carboxylic acid
0.00053
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)furan-2-carboxylic acid
0.00055
-
Mn(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)furan-2-carboxylic acid
0.00067
-
Mn(II)-form of the enzyme Escherichia coli 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
0.00089
-
Mn(II)-form of the enzyme Escherichia coli 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
0.0009 4 Mn(II)-form of the enzyme Escherichia coli 5-(2,3-dichlorophenyl)furan-2-carboxylic acid
0.00118
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
0.00151
-
Mn(II)-form of the enzyme Escherichia coli 5-(2-methylphenyl)thiophene-2-carboxylic acid
0.00275
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
0.00338
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
0.004
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
0.0046
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
0.00499
-
Mn(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)thiophene-2-carboxylic acid
0.00508
-
Mn(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
0.0077
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
0.00889
-
Mn(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
0.0095
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
0.0097
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
0.0099
-
Co(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
0.0264
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)furan-2-carboxylic acid
0.0273
-
Co(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)thiophene-2-carboxylic acid
0.0286
-
Co(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
0.03
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,3-dichlorophenyl)furan-2-carboxylic acid
0.0357
-
Co(II)-form of the enzyme Escherichia coli 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
0.0359
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
0.0373
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,4-dichlorophenyl)furan-2-carboxylic acid
0.0381
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
0.0419
-
Co(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)furan-2-carboxylic acid
0.0457
-
Ni(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)thiophene-2-carboxylic acid
0.0477
-
Fe(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)thiophene-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,3-dichlorophenyl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,4-dichlorophenyl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2-methylphenyl)thiophene-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
0.05
-
Co(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)furan-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(2-methylphenyl)thiophene-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
0.05
-
Fe(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(4-methylnaphthalen-1-yl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,3-dichlorophenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,4-dichlorophenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,3-dimethoxyphenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)furan-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2-methylphenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2-ethoxyphenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2-(trifluoromethyl)phenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,3-dimethylphenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,5-dimethylphenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,4-dimethoxyphenyl)thiophene-2-carboxylic acid
0.05
-
Ni(II)-form of the enzyme Escherichia coli 5-(2,5-dimethoxyphenyl)thiophene-2-carboxylic acid
0.132
-
Co(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)furan-2-carboxylic acid
0.2
-
Fe(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)furan-2-carboxylic acid
0.2
-
Ni(II)-form of the enzyme Escherichia coli 5-(2-methoxyphenyl)furan-2-carboxylic acid