Literature summary for 3.4.11.18 extracted from

Hu, X.; Addlagatta, A.; Matthews, B.W.; Liu, J.O.
Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases (2006), Angew. Chem., 45, 3772-3775.

Search for more literature for 3.4.11.18

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane	-	Homo sapiens
5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine	-	Homo sapiens
5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine	-	Homo sapiens
5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50579	-	-
Homo sapiens	P53582	-	-

Synonyms

Synonyms	Comment	Organism
MetAP1	-	Homo sapiens
MetAP2	-	Homo sapiens
methionine aminopeptidase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0004	-	MetAP1	Homo sapiens	5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine
0.0006	-	MetAP1	Homo sapiens	5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0008	-	MetAP2	Homo sapiens	5-chloro-4-methyl-2-pyridin-2-yl-6-pyrrolidin-1-ylpyrimidine
0.0011	-	MetAP1	Homo sapiens	1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane
0.0033	-	MetAP1	Homo sapiens	5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0033	-	MetAP2	Homo sapiens	5-chloro-N,6-dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0076	-	MetAP2	Homo sapiens	5-chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine
0.0081	-	MetAP2	Homo sapiens	1-(5-chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-4-(2,4-dichlorobenzyl)-1,4-diazepane

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Release 2023.1 (January 2023)