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Literature summary for 3.4.11.18 extracted from

  • Mitra, S.; Dygas-Holz, A.M.; Jiracek, J.; Zertova, M.; Zakova, L.; Holz, R.C.
    A new colorimetric assay for methionyl aminopeptidases: examination of the binding of a new class of pseudopeptide analog inhibitors (2006), Anal. Biochem., 357, 43-49.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-MetStaCys
-
Escherichia coli
L-MetStaCys
-
Pyrococcus furiosus
L-MetStaVal
-
Escherichia coli
L-MetStaVal
-
Pyrococcus furiosus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.59
-
L-Met-p-nitroanilide in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Pyrococcus furiosus
3
-
L-Met-p-nitroanilide in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Escherichia coli
5.1
-
Met-Gly-Met-Met in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Pyrococcus furiosus
18.3
-
Met-Gly-Met-Met in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Met-p-nitroanilide + H2O
-
Escherichia coli p-nitroaniline + L-Met
-
?
L-Met-p-nitroanilide + H2O
-
Pyrococcus furiosus p-nitroaniline + L-Met
-
?
Met-Gly-Met-Met + H2O
-
Escherichia coli Gly-Met-Met + Met
-
?
Met-Gly-Met-Met + H2O
-
Pyrococcus furiosus Gly-Met-Met + Met
-
?

Synonyms

Synonyms Comment Organism
MetAP-I
-
Escherichia coli
MetAP-II
-
Pyrococcus furiosus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.006
-
L-Met-p-nitroanilide in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Escherichia coli
0.057
-
L-Met-p-nitroanilide in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Pyrococcus furiosus
18.3
-
Met-Gly-Met-Met in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Escherichia coli
188
-
Met-Gly-Met-Met in 25 mM HEPES buffer at 30°C (pH 7.5) with 150 mM KCl Pyrococcus furiosus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0017
-
in 25 mM HEPES buffer at 30°C (pH 7.5) Pyrococcus furiosus L-MetStaCys
0.002
-
in 25 mM HEPES buffer at 30°C (pH 7.5) Pyrococcus furiosus L-MetStaVal
0.0025
-
in 25 mM HEPES buffer at 30°C (pH 7.5) Escherichia coli L-MetStaCys
0.0043
-
in 25 mM HEPES buffer at 30°C (pH 7.5) Escherichia coli L-MetStaVal