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Literature summary for 3.4.11.18 extracted from

  • Hu, X.; Dang, Y.; Tenney, K.; Crews, P.; Tsai, C.W.; Sixt, K.M.; Cole, P.A.; Liu, J.O.
    Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases (2007), Chem. Biol., 14, 764-774.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
bengamide A nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
bengamide B nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
bengamide G nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
bengamide L nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
bengamide M nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
bengamide N nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
bengamide O nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
fumagillin MetAP2-specific inhibitor Homo sapiens
IV-43 MetAP1-specific inhibitor Homo sapiens
LAF 389 nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 Homo sapiens
ovalicin MetAP2-specific inhibitor Homo sapiens
TNP-470 MetAP2-specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Met-peptide + H2O Homo sapiens
-
Met + peptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50579
-
-
Homo sapiens P53582
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Met-peptide + H2O
-
Homo sapiens Met + peptide
-
?

Synonyms

Synonyms Comment Organism
MetAP1 isozyme Homo sapiens
MetAP2 isozyme Homo sapiens
methionine aminopeptidase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0019
-
MetAP1 Homo sapiens bengamide A
0.0027
-
MetAP1 Homo sapiens bengamide O
0.0054
-
MetAP1 Homo sapiens bengamide M
0.0105
-
MetAP2 Homo sapiens bengamide A
0.0179
-
MetAP2 Homo sapiens bengamide B
0.0268
-
MetAP1 Homo sapiens bengamide G
0.0293
-
MetAP1 Homo sapiens bengamide B
0.0371
-
MetAP1 Homo sapiens bengamide L
0.0402
-
MetAP1 Homo sapiens bengamide N
0.05
-
IC50 above 0.05 mM, MetAP2 Homo sapiens bengamide G
0.05
-
IC50 above 0.05 mM, MetAP2 Homo sapiens bengamide L
0.05
-
IC50 above 0.05 mM, MetAP2 Homo sapiens bengamide M
0.05
-
IC50 above 0.05 mM, MetAP2 Homo sapiens bengamide N
0.05
-
IC50 above 0.05 mM, MetAP2 Homo sapiens bengamide O