Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bengamide A | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
bengamide B | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
bengamide G | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
bengamide L | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
bengamide M | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
bengamide N | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
bengamide O | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
fumagillin | MetAP2-specific inhibitor | Homo sapiens | |
IV-43 | MetAP1-specific inhibitor | Homo sapiens | |
LAF 389 | nonselective inhibitor for both MetAP1 and MetAP2; nonselective inhibitor for both MetAP1 and MetAP2 | Homo sapiens | |
ovalicin | MetAP2-specific inhibitor | Homo sapiens | |
TNP-470 | MetAP2-specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | Homo sapiens | - |
Met + peptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50579 | - |
- |
Homo sapiens | P53582 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | - |
Homo sapiens | Met + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP1 | isozyme | Homo sapiens |
MetAP2 | isozyme | Homo sapiens |
methionine aminopeptidase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0019 | - |
MetAP1 | Homo sapiens | bengamide A | |
0.0027 | - |
MetAP1 | Homo sapiens | bengamide O | |
0.0054 | - |
MetAP1 | Homo sapiens | bengamide M | |
0.0105 | - |
MetAP2 | Homo sapiens | bengamide A | |
0.0179 | - |
MetAP2 | Homo sapiens | bengamide B | |
0.0268 | - |
MetAP1 | Homo sapiens | bengamide G | |
0.0293 | - |
MetAP1 | Homo sapiens | bengamide B | |
0.0371 | - |
MetAP1 | Homo sapiens | bengamide L | |
0.0402 | - |
MetAP1 | Homo sapiens | bengamide N | |
0.05 | - |
IC50 above 0.05 mM, MetAP2 | Homo sapiens | bengamide G | |
0.05 | - |
IC50 above 0.05 mM, MetAP2 | Homo sapiens | bengamide L | |
0.05 | - |
IC50 above 0.05 mM, MetAP2 | Homo sapiens | bengamide M | |
0.05 | - |
IC50 above 0.05 mM, MetAP2 | Homo sapiens | bengamide N | |
0.05 | - |
IC50 above 0.05 mM, MetAP2 | Homo sapiens | bengamide O |