Protein Variants | Comment | Organism |
---|---|---|
A362T | type II enzyme, mutation results in resistance to ovalicin, TNP-470 and fumagillin when expressed in yeast | Homo sapiens |
H382Y | type II enzyme, mutation results in resistance to ovalicin, TNP-470 and fumagillin when expressed in yeast | Homo sapiens |
T334A | type I enzyme, mutation renders the resistant wild-type enzyme sensitive to ovalicin | Homo sapiens |
Y444C | type II enzyme, mutation results in resistance to TNP-470, but not to fumagillin when expressed in yeast | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fumagillin | inhibition of type II enzyme | Homo sapiens | |
ovalicin | inhibition of type II enzyme | Homo sapiens | |
TNP-470 | inhibition of type II enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
type I and type II enzyme | - |