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Literature summary for 3.4.11.18 extracted from

  • Brdlik, C.M.; Crews, C.M.
    A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases (2004), J. Biol. Chem., 279, 9475-9480.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A362T type II enzyme, mutation results in resistance to ovalicin, TNP-470 and fumagillin when expressed in yeast Homo sapiens
H382Y type II enzyme, mutation results in resistance to ovalicin, TNP-470 and fumagillin when expressed in yeast Homo sapiens
T334A type I enzyme, mutation renders the resistant wild-type enzyme sensitive to ovalicin Homo sapiens
Y444C type II enzyme, mutation results in resistance to TNP-470, but not to fumagillin when expressed in yeast Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fumagillin inhibition of type II enzyme Homo sapiens
ovalicin inhibition of type II enzyme Homo sapiens
TNP-470 inhibition of type II enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
type I and type II enzyme
-