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Literature summary for 3.4.11.18 extracted from

  • Cooper, A.C.; Karp, R.M.; Clark, E.J.; Taghizadeh, N.R.; Hoyt, J.G.; Labenski, M.T.; Murray, M.J.; Hannig, G.; Westlin, W.F.; Thompson, C.D.
    A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo (2006), Clin. Cancer Res., 12, 2583-2590.
    View publication on PubMed
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Application

Application Comment Organism
medicine inhibitor PPI-2458 potently inhibits growth of several non-Hodgkin's lymphoma cell lines in a manner correlating with enzyme inhibition Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fumagillin
-
 Homo sapiens
PPI-2458
-
 Homo sapiens
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester PPI-2458 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Met-peptide + H2O Homo sapiens
-
 Met + peptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P50579
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell lymphoma cell
-
 Homo sapiens
-
germinal center
-
 Homo sapiens
-
lymphoma cell non-Hodgkin's lymphoma cell lines Homo sapiens
-
SR cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Met-peptide + H2O
-
 Homo sapiens Met + peptide
-
 ?

Synonyms

Synonyms Comment Organism
MetAP-2
-
 Homo sapiens
methionine aminopeptidase-2
-
 Homo sapiens