Application | Comment | Organism |
---|---|---|
medicine | MetAP2 is a molecular target for antiangiogenesis and anticancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A-310840 | IC50: 0.000031 mM for enzyme with Zn2+, 0.000043 mM for enzyme with Ni2+, 0.000069 mM for enzyme with Co2+, 0.000026 for enzyme with Fe2+, 0.0578 mM for enzyme with Mn2+ | Homo sapiens | |
A-311263 | IC50: 0.000121 mM for enzyme with Zn2+, 0.000107 mM for enzyme with Ni2+, 0.000149 mM for enzyme with Co2+, 0.00011 mM for enzyme with Fe2+, 0.000055 mM for enzyme with Mn2+ | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 0.0001-0.001 mM, activity is enhanced 5-10fold | Homo sapiens | |
Co2+ | stimulates activity of MetAP2 with Met-Ala-Ser or Met-Gly-Ala-Gln-Phe-Ser-Lys-Thr 10-20fold, maximal stimulation at 0.01 mM. In presence of 5 mM glutathione 30-40fold stimulation | Homo sapiens | |
Mn2+ | stimulates activity of MetAP2 with Met-Ala-Ser or Met-Gly-Ala-Gln-Phe-Ser-Lys-Thr 10-20fold, maximal stimulation at 0.001 mM. In presence of 5 mM glutathione 30-40fold stimulation | Homo sapiens | |
Zn2+ | 0.0001-0.001 mM, activity of MetAP2 is enhanced 5-10fold | Homo sapiens | |
Zn2+ | Zn2+ is the best metal cofactor for MetAP1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
methionine aminopeptidase type 2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | neonatal dermal microvascular | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-Ala-Ser + H2O | - |
Homo sapiens | Met + Ala-Ser | - |
? | |
Met-Ala-Ser-Lys-(biotin)-Gly + H2O | - |
Homo sapiens | Met + Ala-Ser-Lys-(biotin)-Gly | - |
? | |
Met-Gly-Ala-Gln-Phe-Ser-Lys-Thr + H2O | - |
Homo sapiens | Met + Gly-Ala-Gln-Phe-Ser-Lys-Thr | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0517 | - |
Met-Ala-Ser | pH 7.4, MetAP2 | Homo sapiens | |
0.0683 | - |
Met-Gly-Ala-Gln-Phe-Ser-Lys-Thr | pH 7.4, MetAP2 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000031 | - |
IC50: 0.000031 mM for enzyme with Zn2+, 0.000043 mM for enzyme with Ni2+, 0.000069 mM for enzyme with Co2+, 0.000026 for enzyme with Fe2+, 0.0578 mM for enzyme with Mn2+ | Homo sapiens | A-310840 | |
0.000121 | - |
IC50: 0.000121 mM for enzyme with Zn2+, 0.000107 mM for enzyme with Ni2+, 0.000149 mM for enzyme with Co2+, 0.00011 mM for enzyme with Fe2+, 0.000055 mM for enzyme with Mn2+ | Homo sapiens | A-311263 |