Literature summary for 3.4.11.1 extracted from

Rinaldi, G.; Morales, M.E.; Alrefaei, Y.N.; Cancela, M.; Castillo, E.; Dalton, J.P.; Tort, J.F.; Brindley, P.J.
RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs (2009), Mol. Biochem. Parasitol., 167, 118-126.

Search for more literature for 3.4.11.1

Cloned(Commentary)

Cloned (Comment)	Organism
SmLAP1 and SmLAP2, cloning of two discrete LAPs genes, DNA and amino acid sequence determination, genome loci structure, phylogenetic tree, overview	Schistosoma mansoni

Protein Variants

Protein Variants	Comment	Organism
additional information	RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs, overview. Knockdown of eitherSmLAP1 orSmLAP2, or both together, is accompanied by over 80% inhibition of hatching of schistosome eggs	Schistosoma mansoni

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	activates	Schistosoma mansoni

Organism

Organism	UniProt	Comment	Textmining
Schistosoma mansoni	P91803	two discrete LAPs genes, SmLAP1 and SmLAP2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
egg	LAP plays a central role in hatching of the miracidium from the schistosome egg	Schistosoma mansoni	-
additional information	the SmLAP1 andSmLAP2 genes have different expression patterns in diverse stages of the cycle. Whereas both are equally expressed in the blood dwelling stages, schistosomules and adult,SmLAP2 expression is higher in free living larval, miracidia, and in parasitic intra-snail, sporocysts, stages	Schistosoma mansoni	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-leucine-4-methylcoumaryl-7-amide + H2O	-	Schistosoma mansoni	L-leucine + 7-amino-4-methylcoumarine	-	?

Synonyms

Synonyms	Comment	Organism
LAP	-	Schistosoma mansoni
leucine aminopeptidase	-	Schistosoma mansoni

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Schistosoma mansoni

General Information

General Information	Comment	Organism
physiological function	LAP plays a central role in hatching of the miracidium from the schistosome egg	Schistosoma mansoni

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Release 2023.1 (January 2023)