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Literature summary for 3.4.11.1 extracted from

  • Huang, H.; Tanaka, H.; Hammock, B.D.; Morisseau, C.
    Novel and highly sensitive fluorescent assay for leucine aminopeptidases (2009), Anal. Biochem., 391, 11-16.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.065
-
N-(6-methoxypyridin-3-yl)-(S)-2-amino-4-methylpentanamide pH 8.0, 31°C Sus scrofa
3
-
L-leucine-4-nitroanilide pH 8.0, 31°C Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.044
-
kidney enzyme, substrate is N-(6-methoxy-2-methylpyridin-3-yl)-(S)-2-amino-4-methylpentanamide Sus scrofa
5.1
-
kidney enzyme, substrate is L-leucine-4-nitroanilide Sus scrofa
6.5
-
kidney enzyme, substrate is N-(6-methoxypyridin-3-yl)-(S)-2-amino-4-methylpentanamide Sus scrofa
8.4
-
kidney enzyme, substrate is (S)-2-amino-N-(6-(dimethylamino)pyridin-3-yl)-4-methylpentanamide Sus scrofa
9.6
-
kidney enzyme, substrate is L-leucyl-4-methylcoumaryl 7-amide Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-amino-N-(6-(dimethylamino)pyridin-3-yl)-4-methylpentanamide + H2O
-
Sus scrofa ?
-
?
L-leucine-4-methylcoumaryl-7-amide + H2O
-
Sus scrofa L-leucine + 7-amino-4-methylcoumarine
-
?
L-leucine-4-nitroanilide + H2O
-
Sus scrofa L-leucine + 4-nitroaniline
-
?
additional information substrate synthesis and assay method optimization, overview Sus scrofa ?
-
?
N-(6-methoxy-2-methylpyridin-3-yl)-(S)-2-amino-4-methylpentanamide + H2O
-
Sus scrofa ?
-
?
N-(6-methoxypyridin-3-yl)-(S)-2-amino-4-methylpentanamide + H2O
-
Sus scrofa ?
-
?
N-(tert-butoxycarbonyl)-L-leucine + H2O
-
Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
LAP
-
Sus scrofa
leucine aminopeptidase
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
31
-
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
pH 8.0, 31°C, versus substrate L-leucine-4-nitroanilide Sus scrofa bestatin
0.025
-
pH 8.0, 31°C, versus substrate N-(6-methoxypyridin-3-yl)-(S)-2-amino-4-methylpentanamide Sus scrofa bestatin