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Literature summary for 3.4.11.1 extracted from

  • Russo, S.; Baumann, U.
    Crystal structure of a dodecameric tetrahedral-shaped aminopeptidase (2004), J. Biol. Chem., 279, 51275-51281.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Pyrococcus horikoshii

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method. The quaternary structure is built by dimers with a length of 100 A that form the edges of the tetrahedron. All 12 active sites are located on the inside of the tetrahedron. Substrate access is granted by pores with a maximal diameter of 10 A, allowing only small peptides and unfolded proteins access to the active site Pyrococcus horikoshii

Organism

Organism UniProt Comment Textmining
Pyrococcus horikoshii O59196
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-
Pyrococcus horikoshii OT-3 O59196
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-

Purification (Commentary)

Purification (Comment) Organism
-
Pyrococcus horikoshii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine 4-nitroanilide + H2O about 20% of the activity compared to Leu-4-nitroanilide Pyrococcus horikoshii L-alanine + 4-nitroaniline
-
?
L-alanine 4-nitroanilide + H2O about 20% of the activity compared to Leu-4-nitroanilide Pyrococcus horikoshii OT-3 L-alanine + 4-nitroaniline
-
?
L-glutamate 4-nitroanilide + H2O about 20% of the activity compared to Leu-4-nitroanilide Pyrococcus horikoshii L-glutamate + 4-nitroaniline
-
?
L-glutamate 4-nitroanilide + H2O about 20% of the activity compared to Leu-4-nitroanilide Pyrococcus horikoshii OT-3 L-glutamate + 4-nitroaniline
-
?
L-leucine 4-nitroanilide + H2O
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Pyrococcus horikoshii leucine + 4-nitroaniline
-
?
L-leucine 4-nitroanilide + H2O
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Pyrococcus horikoshii OT-3 leucine + 4-nitroaniline
-
?
L-methionine 4-nitroanilide + H2O about 25% of the activity compared to Leu-4-nitroanilide Pyrococcus horikoshii L-methionine + 4-nitroaniline
-
?
L-methionine 4-nitroanilide + H2O about 25% of the activity compared to Leu-4-nitroanilide Pyrococcus horikoshii OT-3 L-methionine + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
dodecamer
-
Pyrococcus horikoshii

Synonyms

Synonyms Comment Organism
FrvX
-
Pyrococcus horikoshii