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Literature summary for 3.4.11.1 extracted from

  • Straeter, N.; Lipscomb, W.N.
    Leucyl aminopeptidase (animal) (2004), Handbook of Proteolytic Enzymes (2nd Edition), 1, 896-901.
No PubMed abstract available
Search for more literature for 3.4.11.1

Inhibitors

Inhibitors Comment Organism Structure
amastatin transition-state analogue Bos taurus
amastatin transition-state analogue, low toxicity in vivo Homo sapiens
amastatin transition-state analogue Sus scrofa
bestatin transition-state analogue Bos taurus
bestatin transition-state analogue Homo sapiens
bestatin transition-state analogue Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol kidney enzyme Sus scrofa 5829
-
additional information the enzyme is associated with the proteasome Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ metallopeptidase Homo sapiens
Zn2+ metallopeptidase Sus scrofa
Zn2+ metallopeptidase Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme has tissue-specifici physiological roles, e.g. trimmíng of the N-terminus of antigenic peptides for presentation or in eye cataract, overview ?
-
 ?
additional information Sus scrofa the enzyme has tissue-specifici physiological roles, overview ?
-
 ?
additional information Bos taurus the enzyme has tissue-specifici physiological roles, overview, active site structure and zinc-binding, mechanism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from kidney to homogeneity Sus scrofa
native enzyme from lens to homogeneity Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation purified kidney enzyme Sus scrofa
-
eye
-
 Homo sapiens
-
intestinal mucosa
-
 Sus scrofa
-
kidney
-
 Sus scrofa
-
lens
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme has tissue-specifici physiological roles, e.g. trimmíng of the N-terminus of antigenic peptides for presentation or in eye cataract, overview Homo sapiens ?
-
 ?
additional information the enzyme has tissue-specifici physiological roles, overview Sus scrofa ?
-
 ?
additional information the enzyme has tissue-specifici physiological roles, overview, active site structure and zinc-binding, mechanism Bos taurus ?
-
 ?
additional information substrate specificity, overview, active site structure Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
LAP
-
 Homo sapiens
LAP
-
 Sus scrofa
LAP
-
 Bos taurus
leucyl aminopeptidase (animal)
-
 Homo sapiens
leucyl aminopeptidase (animal)
-
 Sus scrofa
leucyl aminopeptidase (animal)
-
 Bos taurus
More the enzyme belongs to the peptidase family M17 Homo sapiens
More the enzyme belongs to the peptidase family M17 Sus scrofa
More the enzyme belongs to the peptidase family M17 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5 kidney enzyme Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000013
-
 amastatin lens enzyme Bos taurus
0.0002
-
 amastatin kidney enzyme Sus scrofa