Cloned (Comment) | Organism |
---|---|
genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K528R | A-LAP polymorphism, leads to hypertension | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | A-LAP ia a zinc-metallopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Homo sapiens | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
additional information | Homo sapiens | A-LAP plays a key role in the MHC class I antigen-presentation pathway, the enzyme is involved in the renin-angiotensin-system, RAS, and angiotensin II metabolism, and plays a role in blood pressure decrease through inactivation of angiotensin II, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Homo sapiens | - |
kidney | cortex | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | Homo sapiens | Asp + angiotensin III | i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
kallidin + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | A-LAP plays a key role in the MHC class I antigen-presentation pathway, the enzyme is involved in the renin-angiotensin-system, RAS, and angiotensin II metabolism, and plays a role in blood pressure decrease through inactivation of angiotensin II, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A-LAP | - |
Homo sapiens |
leucine aminopeptidase | - |
Homo sapiens |
More | the enzyme belongs to the M1 peptidase family | Homo sapiens |