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Literature summary for 3.3.2.9 extracted from

  • Nithipatikom, K.; Endsley, M.P.; Pfeiffer, A.W.; Falck, J.R.; Campbell, W.B.
    A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol (2014), J. Lipid Res., 55, 2093-2102.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
10-hydroxystearamide
-
Homo sapiens
3-(decylthio)-1,1,1-trifluoropropan-2-one moderate inhibition Homo sapiens
3-(dodecylthio)-1,1,1-trifluoropropan-2-one moderate inhibition Homo sapiens
3-(octylthio)-1,1,1-trifluoropropan-2-one moderate inhibition Homo sapiens
methoxyarachidonyl fluorophosphate
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.042
-
2-arachidonoylglycerol at pH 7.4 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis-stilbene oxide + H2O Homo sapiens
-
(+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
LNCaP cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
Homo sapiens arachidonic acid + glycerol
-
?
cis-stilbene oxide + H2O
-
Homo sapiens (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
?
additional information no activity with 14,15-epoxyexicosatrienoic acid Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
EPHX1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000079
-
at pH 7.4 and 37°C Homo sapiens methoxyarachidonyl fluorophosphate

General Information

General Information Comment Organism
metabolism the enzyme plays a role in the endocannabinoid signaling and a new arachidonic acid biosynthetic pathway Homo sapiens