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Literature summary for 3.3.2.9 extracted from

  • Marowsky, A.; Burgener, J.; Falck, J.R.; Fritschy, J.M.; Arand, M.
    Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism (2009), Neuroscience, 163, 646-661.
    View publication on PubMed
Search for more literature for 3.3.2.9

Cloned(Commentary)

Cloned (Comment) Organism
expression pattern of mEH Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00025
-
 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid
-
 Mus musculus
0.0005
-
 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid
-
 Mus musculus
0.001
-
 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid
-
 Mus musculus
0.001
-
 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala specific nuclei Mus musculus
-
astrocyte
-
 Mus musculus
-
brain mEH distribution, immunohistochemical analysis, overview. mEH immunoreactivity is present in specific neuronal populations of the hippocampus, striatum, amygdala, and cerebellum, as well as in a fraction of astrocytes Mus musculus
-
cerebellum
-
 Mus musculus
-
choroid plexus
-
 Mus musculus
-
corpus striatum
-
 Mus musculus
-
hindbrain specific nuclei Mus musculus
-
hippocampus
-
 Mus musculus
-
midbrain specific nuclei Mus musculus
-
neuron
-
 Mus musculus
-
vascular cell endothelial and smooth muscle cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
mEH
-
 Mus musculus

General Information

General Information Comment Organism
metabolism epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids. Microsomal epoxide hydrolase is involved in the cerebral epoxyeicosatrienoic acid metabolism Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.01
-
 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid
-
 Mus musculus
0.01
-
 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid
-
 Mus musculus
0.02
-
 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid
-
 Mus musculus
5
-
 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid
-
 Mus musculus