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Literature summary for 3.3.2.9 extracted from

  • Jain, M.; Tilak, A.R.; Upadhyay, R.; Kumar, A.; Mittal, B.
    Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer (2008), Toxicol. Appl. Pharmacol., 230, 247-251.
    View publication on PubMed
Search for more literature for 3.3.2.9

Application

Application Comment Organism
medicine patients with exon 3 genotypes (Tyr113His, His113His) and 113His allele are at risk of squamous cell esophageal cancer, none of haplotype combinations of exon 3 (Y113H) and exon 4 (H139R) polymorphisms show modulation of risk for squamous cell esophageal cancer Homo sapiens

Protein Variants

Protein Variants Comment Organism
H139R the mutant exhibits low risk for squamous cell esophageal cancer Homo sapiens
Y113H the mutation is associated with higher risk of squamous cell esophageal cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-stilbene oxide + H2O
-
 Homo sapiens (1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Synonyms

Synonyms Comment Organism
EPHX1
-
 Homo sapiens