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Literature summary for 3.3.2.9 extracted from

  • Pushparajah, D.S.; Umachandran, M.; Plant, K.E.; Plant, N.; Ioannides, C.
    Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices (2008), Mutat. Res., 640, 153-161.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information benzo[a]pyrene, dibenzo[a,h]anthracene and fluoranthene give rise to a statistically significant increase in epoxide hydrolase activity, which is accompanied by a concomitant increase in epoxide hydrolase protein levels, dibenzo[a,l]pyrene, benzo[b]fluoranthene and 1-methylphenanthrene, influence neither activity nor enzyme protein levels Homo sapiens
additional information benzo[a]pyrene, dibenzo[a,h]anthracene and fluoranthene give rise to a statistically significant increase in epoxide hydrolase activity, which is accompanied by a concomitant increase in epoxide hydrolase protein levels, dibenzo[a,l]pyrene, benzo[b]fluoranthene and 1-methylphenanthrene, influence neither activity nor enzyme protein levels Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
lung in the rat basal lung epoxide hydrolase activity is much lower than liver Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzo[a]pyrene 5-oxide + H2O
-
Homo sapiens ?
-
?
benzo[a]pyrene 5-oxide + H2O
-
Rattus norvegicus ?
-
?
cis-stilbene oxide + H2O
-
Homo sapiens (1R,2R)-1,2-diphenylethane-1,2-diol
-
?
cis-stilbene oxide + H2O
-
Rattus norvegicus (1R,2R)-1,2-diphenylethane-1,2-diol
-
?