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Literature summary for 3.3.2.9 extracted from

  • Lacko, M.; Roelofs, H.M.; Te Morsche, R.H.; Voogd, A.C.; Oude Ophuis, M.B.; Peters, W.H.; Manni, J.J.
    Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer (2008), Head Neck, 30, 836-844.
    View publication on PubMed
Search for more literature for 3.3.2.9

Application

Application Comment Organism
medicine there is no risk-modifying effect of genetic polymorphisms in microsomal epoxide hydrolase on head and neck carcinogenesis, except for the predicted high activity variant H139R in patients with hypopharyngeal carcinoma Homo sapiens

Protein Variants

Protein Variants Comment Organism
H139R the mutation enhances enzyme activity by approximately 25% Homo sapiens
Y113H the mutant is associated with 40-50% decrease in microsomal epoxide hydrolase activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-stilbene oxide + H2O
-
 Homo sapiens (1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Synonyms

Synonyms Comment Organism
mEH
-
 Homo sapiens