Literature summary for 3.3.2.9 extracted from

Morisseau, C.; Newman, J.W.; Wheelock, C.E.; Hill Iii, T.; Morin, D.; Buckpitt, A.R.; Hammock, B.D.
Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase (2008), Chem. Res. Toxicol., 21, 951-957.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in a baculovirus expression system in High Five insect cell cultures (derived from Trichoplusia ni)	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
2-nonylsulfanyl-propionamide	-	Rattus norvegicus
elaidamide	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Q-Sepharose column chromatography	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cis-stilbene oxide + H2O	-	Rattus norvegicus	(1R,2R)-1,2-diphenylethane-1,2-diol	-	?

Synonyms

Synonyms	Comment	Organism
mEH	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000072	-	2-nonylsulfanyl-propionamide	in Tris/HCl buffer (0.1 M, pH 9.0), at 30°C	Rattus norvegicus

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Release 2023.1 (January 2023)